The largest organ in the human body is the skin, which is a living, breathing organ, constantly in growth and regeneration. Underlying cells grow to replace the old ones that are shed. As we age, the stem cell activity and ability to grow and maintain new cells will reduce. This may lead to visible signs of ageing, like saggy skin, wrinkles, and age spots. Our formulated stem cell treatment can optimally increase skin texture and firmness, decrease pigmentation and improve overall skin health.

As the skin ages, the intrinsic stem cell activity is decreased, resulting in the skin losing its fluid content and fullness, along with loss of subcutaneous fat cells. Volume decrease with loss of skin elasticity results in sagging of skin, and the appearance of fine crepe-like lines and wrinkles. Reduced stem cell activity also results in decreased skin cell turnover and persistence of cells damaged by ultraviolet rays or other detrimental environmental factors.

Application of the protein from stem cells has been found to improve skin texture and firmness, decrease pigmentation, and overall, improve skin health.

Culturing human other types of stem cells require a feeder layer, i.e. a layer of cells under the cells that are grown, to support the nutritional requirements of the stem cells and to maintain their stemness i.e. to preserve their pluripotent stem cell nature.

Over the years, both human and animal cells have been used for this purpose.  Human cells are preferable as they do not contain animal (e.g. mouse) genes, which may move into the overlying human cells, altering their behaviour.

Our collaborator Professor Kam Leong at the Duke-NUS Graduate School of Medicine, Singapore employed Cord Lining Stem Cells as a feeder layer for cord blood haematopoietic stem cells and we are pleased to report that this research has been a great success. It may be the standard for feeder layer support for other stem cell researchers in the future.

It is our commitment to you at CellResearch Corporation not to rest on our laurels - research and development has to continue and we are pleased to report it is coming along very well indeed.

The below outline research projects using Cord Lining Stem cells that are ongoing in Singapore and in other parts of the world. We shall certainly continue expanding our research collaborations. It is such cooperation that will bring Cord Lining Stem Cells to the fore, and advance translational therapy in the not too distant future.

SINGAPORE

Organisation: National Cancer Centre (NCC)

Collaborator: Prof Kon O L

Project: Use of CLSC as a carrier of Factor VIII gene for treatment of Haemophilia A

Organisation: National Cancer Centre (NCC)

Collaborator: Prof Kon O L

Project: Use of CLSC for treatment of diabetes (non-viral transfection)

Organisation: National University of Singapore (NUS), Surgery and University of Cambridge

Collaborator: Prof Lee K O, Prof Sir Roy Calne

Project: Use of CLSC for treatment of diabetes (viral transfection)

Organisation: National University of Singapore (NUS), Surgery

Collaborator: A/Prof Theodore Kofidis and Dr Eliana Martinez

Project: Multicellular Angiogenic Spheroids to improve engraftment of stem cells and bioartificial tissue for myocardial restoration 

Organisation: Singapore Eye Research Institute (SERI)

Collaborator: A/Prof Leonard Ang

Project: Use of CLSC for treatment of eye related diseases and corneal resurfacing

Organisation: DUKE-NUS Graduate School of Medicine

Collaborator: Prof Kam Leong

Project: CLSCs as a suitable feeder layer for ex-vivo expansion of other stem/progenitor cells.

OVERSEAS

Organisation: Stanford University School of Medicine, USA

Collaborator: A/Prof Stefan Heller

Project: CLSC to treat hearing loss including the ability of the cells to develop along the inner ear cell lineage

Organisation: Shriners Hospital for Children – Galveston, USA

Collaborator: Prof David Herndon and Dr Katsuhiro Kita

Project: Use of CLSCs for the treatment of burns 

Organisation: National Hospital of Traditional Medicine and Saint Paul's Hospital Burns Center, Hanoi, Vietnam

Collaborator: Dr Tuan

Project: Use of CLSCs for the treatment of burns and chronic wounds

Organisation: Hospital 103, Hanoi, Vietnam

Collaborator: Dr Han

Project: Use of CLSCs for the treatment of burns and chronic wounds

Organisation: AO Research Institute, Davos Switzerland

Collaborator: Dr. Martin J. Stoddart and Prof. Mauro Alini

Project: Differentiation of CLSC into bone and cartilage for the treatment of bone and cartilage disorders

Organisation: University Heart Center, Hamburg

Collaborator: Prof Sonja Schrepfer and Prof Robert Robbins

Project: Use of CLMCs to study immunology and the potential for cardiac treatment

Organisation: Keele University

Collaborator: Prof James Richardson

Project: Use of CLMCs for the treatment of cartilage disorders

Organisation: Chinese Hong Kong University

Collaborator: Prof Andrew Burd and Dr Linda Huang

Project: Study of CLSCs for the treatment of burns and wounds

Organisation: FBM Regenerative Biology and Medicine JSC (FBM), Hanoi, Vietnam

Collaborator: 

Project: Study of CLSCs for treatment of eye, bone and cartilage disorders and ischemic limb conditions.